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Tackett, Alan

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My laboratory focuses on histone epigenetic mechanisms that regulate gene transcription and that are coupled to melanoma progression. We utilize a suite of techniques in our studies including proteomics of human biopsies, immunohistochemistry, cell culture, tumorigenicity assays, ChIPseq, biochemical and proteomic approaches for analyses of protein complexes, and cutting-edge mass spectrometry for the analysis of histone post-translational modifications. We have a unique environment that provides for discovery-based studies like proteomics as well as hypothesis-driven studies like those we perform in cell culture and with skin biopsies. In addition to our melanoma work, we develop new technologies for epigenetic studies such as tools for detection of in vivo protein interactions and quantitative assays for histone modifying proteins.

One or more keywords matched the following items that are connected to Tackett, Alan

Item Type	Name
Academic Article	Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
Academic Article	Multiple full-length NS3 molecules are required for optimal unwinding of oligonucleotide DNA in vitro.
Academic Article	I-DIRT, a general method for distinguishing between specific and nonspecific protein interactions.
Academic Article	CYP2E1 active site residues in substrate recognition sequence 5 identified by photoaffinity labeling and homology modeling.
Academic Article	NS3 helicase from the hepatitis C virus can function as a monomer or oligomer depending on enzyme and substrate concentrations.
Academic Article	Hepatitis C virus NS3 helicase forms oligomeric structures that exhibit optimal DNA unwinding activity in vitro.
Academic Article	Identification of the major phosphorylation site in Bcl-xL induced by microtubule inhibitors and analysis of its functional significance.
Academic Article	Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen.
Academic Article	Misregulation of Rad50 expression in melanoma cells.
Academic Article	A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates.
Academic Article	Myogenin recruits the histone chaperone facilitates chromatin transcription (FACT) to promote nucleosome disassembly at muscle-specific genes.
Academic Article	Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini.
Academic Article	Physical and functional interaction between yeast Pif1 helicase and Rim1 single-stranded DNA binding protein.
Academic Article	A noncanonical bromodomain in the AAA ATPase protein Yta7 directs chromosomal positioning and barrier chromatin activity.
Academic Article	Synergistic functions of SII and p300 in productive activator-dependent transcription of chromatin templates.
Academic Article	Mapping the local protein interactome of the NuA3 histone acetyltransferase.
Academic Article	ChAP-MS: a method for identification of proteins and histone posttranslational modifications at a single genomic locus.
Academic Article	Analysis of stable and transient protein-protein interactions.
Academic Article	Ringo/cyclin-dependent kinase and mitogen-activated protein kinase signaling pathways regulate the activity of the cell fate determinant Musashi to promote cell cycle re-entry in Xenopus oocytes.
Academic Article	Identification of PTHrP(12-48) as a plasma biomarker associated with breast cancer bone metastasis.
Academic Article	GINS motion reveals replication fork progression is remarkably uniform throughout the yeast genome.
Academic Article	Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs.
Academic Article	Genetic and biochemical evaluation of the importance of Cdc6 in regulating mitotic exit.
Academic Article	Development and evaluation of a structural model for SF1B helicase Dda.
Academic Article	Purification of a specific native genomic locus for proteomic analysis.
Concept	Protein Denaturation
Concept	Protein Kinases
Concept	HMGB2 Protein
Concept	Staphylococcal Protein A
Concept	Protein Processing, Post-Translational
Concept	Sequence Analysis, Protein
Concept	Protein Interaction Mapping
Concept	MyoD Protein
Concept	Parathyroid Hormone-Related Protein
Concept	Protein Structure, Quaternary
Concept	Myeloid-Lymphoid Leukemia Protein
Concept	Protein Binding
Concept	Tumor Suppressor Protein p53
Concept	Protein Interaction Maps
Concept	Poly(A)-Binding Protein I
Concept	Ubiquitin-Protein Ligases
Concept	bcl-X Protein
Concept	Protein Stability
Concept	Glial Fibrillary Acidic Protein
Concept	Retinoblastoma-Binding Protein 2
Concept	Protein Biosynthesis
Concept	Protein Phosphatase 2
Concept	Mitogen-Activated Protein Kinase Kinases
Concept	Protein Kinase Inhibitors
Concept	E1A-Associated p300 Protein
Concept	bcl-2-Associated X Protein
Concept	Protein Structure, Tertiary
Concept	Protein Interaction Domains and Motifs
Concept	Zonula Occludens-1 Protein
Concept	DNA-Activated Protein Kinase
Academic Article	Mitotic phosphorylation of histone H3 threonine 80.
Academic Article	IDIRT, A General Method for Distinguished Between Specific and Non Specific Protein Interactions
Academic Article	TBX2 blocks myogenesis and promotes proliferation in rhabdomyosarcoma cells.
Academic Article	A CRISPR-based approach for proteomic analysis of a single genomic locus.
Academic Article	A PWWP domain-containing protein targets the NuA3 acetyltransferase complex via histone H3 lysine 36 trimethylation to coordinate transcriptional elongation at coding regions.
Academic Article	Purification of specific chromatin loci for proteomic analysis.
Academic Article	Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis.
Academic Article	The bromodomain of Gcn5 regulates site specificity of lysine acetylation on histone H3.
Academic Article	Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma.
Academic Article	Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA.
Academic Article	Proteomic Identification of DNA-PK Involvement within the RET Signaling Pathway.
Academic Article	Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication.
Academic Article	Quantitative Histone Mass Spectrometry Identifies Elevated Histone H3 Lysine 27 (Lys27) Trimethylation in Melanoma.
Academic Article	Age- and Hypertension-Associated Protein Aggregates in Mouse Heart Have Similar Proteomic Profiles.
Academic Article	Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum Complex Regulating Collagen Lysyl Hydroxylation.
Academic Article	Role of EZH2 histone methyltrasferase in melanoma progression and metastasis.
Academic Article	Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls.
Academic Article	Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans.
Academic Article	KDM5 lysine demethylases are involved in maintenance of 3'UTR length.
Academic Article	DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes.
Academic Article	Proteomic identification of histone post-translational modifications and proteins enriched at a DNA double-strand break.
Academic Article	An N6-methyladenosine at the transited codon 273 of p53 pre-mRNA promotes the expression of R273H mutant protein and drug resistance of cancer cells.
Grant	Sirt3: A Key Player Against PCB-Induced Mitochondrial Injury
Grant	Melanocortin-4 Receptor Traffic and Signaling
Grant	Using ChAP-MS to Study Macromolecular Chromatin Composition during Transcription
Grant	Early Events in Alzheimer Pathogenesis
Grant	Analysis of Proteins Involed in Genome Duplication
Grant	Discovery and Target Identification of Senolytic Agents
Grant	Development of technology for high resolution epigenetic profiling of chromatin
Grant	Role of the Leprecan Genes in Skeletal Formation
Grant	Biochemistry of recombination in meiosis
Grant	Identifying the Epigenetic Regulation of Arsenic Exposure
Grant	Lipid Stress and MC4R
Grant	Transgenic analysis of platelet receptor expression
Grant	NIH COBRE Center for Protein Structure and Function
Academic Article	Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation.
Academic Article	Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations.
Academic Article	Histone Modifications as Biomarkers for Immunotherapy.
Academic Article	Exploiting Correlations between Protein Abundance and the Functional Status of saeRS and sarA To Identify Virulence Factors of Potential Importance in the Pathogenesis of Staphylococcus aureus Osteomyelitis.
Academic Article	Utility of histone H3K27me3 and H4K20me as diagnostic indicators of melanoma.
Academic Article	ProteoViz: a tool for the analysis and interactive visualization of phosphoproteomics data.
Academic Article	Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion.
Academic Article	Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity.
Academic Article	ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism.
Academic Article	Dysbiotic stress increases the sensitivity of the tumor vasculature to radiotherapy and c-Met inhibitors.
Academic Article	A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing.
Academic Article	Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy.
Academic Article	Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic.
Academic Article	CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells.
Academic Article	TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons.

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